Integrative alternative splicing analysis reveals new prognosis signature in B-cell acute lymphoblastic leukemia.

ABSTRACT: The dysregulation of alternative splicing (AS) is increasingly recognized as a pivotal player in the pathogenesis, progression, and treatment resistance of B-cell acute lymphoblastic leukemia (B-ALL). Despite its significance, the clinical implications of AS events in B-ALL remain largely unexplored. This study developed a prognostic model based on 18 AS events (18-AS), derived from a meticulous integration of bioinformatics methodologies and advanced machine learning algorithms. The 18-AS signature observed in B-ALL distinctly categorized patients into different groups with significant differences in immune infiltration, V(D)J rearrangement, drug sensitivity, and immunotherapy outcomes. Patients classified within the high 18-AS group exhibited lower immune infiltration scores, poorer chem

SUBMITTER: Zhuo Z 

PROVIDER: S-EPMC11380455 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature