Infarct density defined by ADC threshold is associated with long-term functional outcome after endovascular thrombectomy.

ABSTRACT:

Objectives

Endovascular thrombectomy (EVT) dramatically improves clinical outcomes, but the reduction in final infarct volume only accounts for 10-15 % of the treatment benefit. We aimed to develop a novel MRI-ADC-based metric that quantify the degree of tissue injury to test the hypothesis that it outperforms infarct volume in predicting long-term outcome.

Materials and methods

A single-center cohort consisted of consecutive acute stroke patients with anterior circulation large vessel occlusion, successful recanalization via EVT (mTICI ≥2b), and MRI of the brain between 12 h and 7 days post-EVT. Imaging was processed via RAPID software. Final infarct volume was based on the traditional ADC <620 threshold. Logistic regression quantified the association of lesion volumes and

SUBMITTER: Favilla CG 

PROVIDER: S-EPMC11380574 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature