Saliva antibody profiles are associated with reaction threshold and severity of peanut allergic reactions.

ABSTRACT:

Background

Reaction threshold and severity in food allergy are difficult to predict, and noninvasive predictors are lacking.

Objective

We sought to determine the relationships between pre-challenge levels of peanut (PN)-specific antibodies in saliva and reaction threshold, severity, and organ-specific symptoms during PN allergic reactions.

Methods

We measured PN-specific antibody levels in saliva collected from 127 children with suspected PN allergy before double-blind, placebo-controlled PN challenges in which reaction threshold, severity, and symptoms were rigorously characterized. Low threshold (LT) PN allergy was defined as reaction to <300 mg of PN protein cumulatively consumed. A consensus severity grading system was used to grade severity. We analyzed associati

SUBMITTER: Ho HE 

PROVIDER: S-EPMC11380589 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature