A pediatric randomized, controlled trial of German cockroach subcutaneous immunotherapy.

ABSTRACT:

Background

Cockroach allergy contributes to morbidity among urban children with asthma. Few trials address the effect of subcutaneous immunotherapy (SCIT) with cockroach allergen among these at-risk children.

Objectives

We sought to determine whether nasal allergen challenge (NAC) responses to cockroach allergen would improve following 1 year of SCIT.

Methods

Urban children with asthma, who were cockroach-sensitized and reactive on NAC, participated in a year-long randomized double-blind placebo-controlled SCIT trial using German cockroach extract. The primary endpoint was the change in mean Total Nasal Symptom Score (TNSS) during NAC after 12 months of SCIT. Changes in nasal transcriptomic responses during NAC, skin prick test wheal size, serum allergen-specific anti

SUBMITTER: Zoratti E 

PROVIDER: S-EPMC11380590 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature