Comparative genomics reveal a novel phylotaxonomic order in the genus Fusobacterium.

ABSTRACT: Fusobacteria have been associated to different diseases, including colorectal cancer (CRC), but knowledge of which taxonomic groups contribute to specific conditions is incomplete. We analyzed the genetic diversity and relationships within the Fusobacterium genus. We report recent and ancestral recombination in core genes, indicating that fusobacteria have mosaic genomes and emphasizing that taxonomic demarcation should not rely on single genes/gene regions. Across databases, we found ample evidence of species miss-classification and of undescribed species, which are both expected to complicate disease association. By focusing on a lineage that includes F. periodonticum/pseudoperiodonticum and F. nucleatum, we show that genomes belong to four modern populations, but most known species/subs

SUBMITTER: Molteni C 

PROVIDER: S-EPMC11380691 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature