Trajectories of long-term exposure to PCB153 and Benzo[a]pyrene (BaP) air pollution and risk of breast cancer.

ABSTRACT:

Background

While genetic, hormonal, and lifestyle factors partially elucidate the incidence of breast cancer, emerging research has underscored the potential contribution of air pollution. Polychlorinated biphenyls (PCBs) and benzo[a]pyrene (BaP) are of particular concern due to endocrine-disrupting properties and their carcinogenetic effect.

Objective

To identify distinct long term trajectories of exposure to PCB153 and BaP, and estimate their associations with breast cancer risk.

Methods

We used data from the XENAIR case-control study, nested within the ongoing prospective French E3N cohort which enrolled 98,995 women aged 40-65 years in 1990-1991. Cases were incident cases of primary invasive breast cancer diagnosed from cohort entry to 2011. Controls were randomly

SUBMITTER: Desnavailles P 

PROVIDER: S-EPMC11380782 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature