Paeoniflorin protects hepatocytes from APAP-induced damage through launching autophagy via the MAPK/mTOR signaling pathway.

ABSTRACT:

Background

Drug-induced liver injury (DILI) is gradually becoming a common global problem that causes acute liver failure, especially in acute hepatic damage caused by acetaminophen (APAP). Paeoniflorin (PF) has a wide range of therapeutic effects to alleviate a variety of hepatic diseases. However, the relationship between them is still poorly investigated in current studies.

Purpose

This work aimed to explore the protective effects of PF on APAP-induced hepatic damage and researched the potential molecular mechanisms.

Methods

C57BL/6J male mice were injected with APAP to establish DILI model and were given PF for five consecutive days for treatment. Aiming to clarify the pharmacological effects, the molecular mechanisms of PF in APAP-induced DILI was elucidated by h

SUBMITTER: Deng X 

PROVIDER: S-EPMC11380789 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature