Associations between prenatal stress with offspring inflammation, depression and anxiety.

ABSTRACT:

Purpose

Few longitudinal studies have investigated the mediating role of inflammation during childhood in associations between prenatal maternal stress and adolescent mental health. The objective of this study was to examine the associations between prenatal maternal stress, concentrations of immune markers at age 9, and symptoms of generalized anxiety disorder (GAD) and depression during adolescence.

Methods

This study included 3723 mother-child pairs from the Avon Longitudinal Study of Parents and Children (ALSPAC). Prenatal maternal stress was examined using 55 items measured during pregnancy. Inflammation was assessed using serum concentrations of interleukin-6 (IL-6) and C-reactive protein (CRP) when children were 9 years old. GAD and depression were assessed when child

SUBMITTER: Clayborne ZM 

PROVIDER: S-EPMC11381142 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature