Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice.

ABSTRACT: Cannabidiol (CBD) has gained widespread popularity; however, its pharmacological and toxicological profiles in the context of human genetic diversity remain largely unexplored. Here, we investigated the variability in metabolism and toxicity of CBD-rich cannabis extract (CRCE) in genetically diverse mouse models: C57BL/6J, B6C3F₁/J, and NZO/HlLtJ strains. Mice received a single dose of CRCE containing 57.9% CBD at dosages of 0, 246, 738, and 2460 mg/kg of CBD. At 24 h after treatment, no appreciable histomorphological changes were detected in the liver. Plasma bilirubin levels increased markedly in all strains at the highest CBD dose. Mice in all treatment groups displayed significant but distinct increases in ALT and AST levels. While B6C3F₁/J and NZO/HlLtJ mice had

SUBMITTER: Ewing LE 

PROVIDER: S-EPMC11381146 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature