Classification of Mild Cognitive Impairment and Alzheimer's Disease Using Manual Motor Measures.

ABSTRACT:

Introduction

Manual motor problems have been reported in mild cognitive impairment (MCI) and Alzheimer's disease (AD), but the specific aspects that are affected, their neuropathology, and potential value for classification modeling is unknown. The current study examined if multiple measures of motor strength, dexterity, and speed are affected in MCI and AD, related to AD biomarkers, and are able to classify MCI or AD.

Methods

Fifty-three cognitively normal (CN), 33 amnestic MCI, and 28 AD subjects completed five manual motor measures: grip force, Trail Making Test A, spiral tracing, finger tapping, and a simulated feeding task. Analyses included (1) group differences in manual performance; (2) associations between manual function and AD biomarkers (PET amyloid β, hippocampa

SUBMITTER: Koppelmans V 

PROVIDER: S-EPMC11381162 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature