The association of TNF inhibitor use with incident cardiovascular events in radiographic axial spondyloarthritis.

ABSTRACT:

Background

Whether tumor necrosis factor inhibitor (TNFi) use is cardioprotective among individuals with radiographic axial spondyloarthritis (r-axSpA), who have heightened cardiovascular (CV) risk, is unclear. We tested the association of TNFi use with incident CV outcomes in r-axSpA.

Methods

We identified a r-axSpA cohort within a Veterans Affairs database between 2002 and 2019 using novel phenotyping methods and secondarily using ICD codes. TNFi use was assessed as a time-varying exposure using pharmacy dispense records. The primary outcome was incident CV disease identified using ICD codes for coronary artery disease, myocardial infarction or stroke. We fit Cox models with inverse probability weights to estimate the risk of each outcome with TNFi use versus non-use. Anal

SUBMITTER: Liew JW 

PROVIDER: S-EPMC11381167 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature