Pulmonary surfactant and prostaglandin E₂ in airway smooth muscle relaxation of human and male guinea pigs.

ABSTRACT: Pulmonary surfactant serves as a barrier to respiratory epithelium but can also regulate airway smooth muscle (ASM) tone. Surfactant (SF) relaxes contracted ASM, similar to β₂-agonists, anticholinergics, nitric oxide, and prostanoids. The exact mechanism of surfactant relaxation and whether surfactant relaxes hyperresponsive ASM remains unknown. Based on previous research, relaxation requires an intact epithelium and prostanoid synthesis. We sought to examine the mechanisms by which surfactant causes ASM relaxation. Organ bath measurements of isometric tension of ASM of guinea pigs in response to exogenous surfactant revealed that surfactant reduces tension of healthy and hyperresponsive tracheal tissue. The relaxant effect of surfactant was reduced if prostanoid synthesis was i

SUBMITTER: Hanusrichterova J 

PROVIDER: S-EPMC11381196 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature