Acute-phase plasma proteomics of rabbit lung VX2 tumors treated by image-guided microwave ablation.

ABSTRACT:

Purpose

To explore the plasma proteomic changes of rabbit lung VX2 tumors treated by microwave ablation, and to explore the molecular pathway mechanisms that may be involved.

Methods

New Zealand white rabbits were inoculated with VX2 tumor cell suspension in the right lower lung and treated with microwave ablation after 2-3 weeks of tumor formation. Blood was collected at 5 time points (TP1~TP5) before and after ablation by cardiac blood sampling and pre-treated before proteomic analysis. The plasma proteome was analyzed by Data-Independent Acquisition (DIA).

Results

Different molecular pathways were activated at different time points:(i) TP1vsTP2: more proteins were down-regulated and enrichment analysis showed that the proteasome pathway was activated. The abnormal

SUBMITTER: Cheng L 

PROVIDER: S-EPMC11381224 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature