Primary immunodeficiency-related genes and varicella-zoster virus reactivation syndrome: a Mendelian randomization study.

ABSTRACT:

Background

Currently, evidence regarding the causal relationship between primary immunodeficiency-related genes and varicella-zoster virus reactivation syndrome is limited and inconsistent. Therefore, this study employs Mendelian randomization (MR) methodology to investigate the causal relationship between the two.

Methods

This study selected 110 single-nucleotide polymorphisms (SNPs) of primary immunodeficiency-related genes as instrumental variables (IVs). Genetic associations of primary immunodeficiency-related genes were derived from recent genome-wide association studies (GWAS) data on human plasma protein levels and circulating immune cells. Data on genes associated with varicella-zoster virus reactivation syndrome were obtained from the GWAS Catalog and FINNGEN databa

SUBMITTER: Wang H 

PROVIDER: S-EPMC11381235 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature