GPCRs overexpression and impaired fMLP-induced functions in neutrophils from chronic kidney disease patients.

ABSTRACT:

Introduction

G-protein coupled receptors (GPCRs) expressed on neutrophils regulate their mobilization from the bone marrow into the blood, their half-live in the circulation, and their pro- and anti-inflammatory activities during inflammation. Chronic kidney disease (CKD) is associated with systemic inflammatory responses, and neutrophilia is a hallmark of CKD onset and progression. Nonetheless, the role of neutrophils in CKD is currently unclear.

Methods

Blood and renal tissue were collected from non-dialysis CKD (grade 3 - 5) patients to evaluate GPCR neutrophil expressions and functions in CKD development.

Results

CKD patients presented a higher blood neutrophil-to-lymphocyte ratio (NLR), which was inversely correlated with the glomerular filtration rate (eGFR). A

SUBMITTER: Scharf P 

PROVIDER: S-EPMC11381270 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature