In vitro mechanistic study on mycophenolate mofetil drug interactions: effect of prednisone, cyclosporine, and others.

ABSTRACT:

Objective

The metabolism- and transporter-based drug-drug interactions (DDIs) between mycophenolate mofetil (MMF) and co-administered medications may be key factors for the high individual variability in MMF exposure. This study systematically assessed the influence of co-medications on the mycophenolic acid (MPA) pharmacokinetic (PK) process in vitro, particularly to provide mechanistic evidence of the metabolic interaction among steroids, cyclosporine (CsA), and MMF.

Methods

Based on a previous study, we hypothesized that there are three main DDI pathways affecting MMF PK in vivo. A human hepatocyte induction study, transporter substrate/inhibition study using human embryonic kidney 293 cells, and multidrug resistance-associated protein 2 (MRP2) substrate/inh

SUBMITTER: Mao J 

PROVIDER: S-EPMC11381307 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature