Proven anti-virulence therapies in combating methicillin- and vancomycin-resistant Staphylococcus aureus infections.

ABSTRACT:

Introduction

Despite years of efforts to develop new antibiotics for eradicating multidrug-resistant (MDR) and multi-virulent Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Staphylococcus aureus (VRSA) infections, treatment failures and poor prognoses in most cases have been common. Therefore, there is an urgent need for new therapeutic approaches targeting virulence arrays. Our aim is to discover new anti-virulence therapies targeting MRSA and VRSA virulence arrays.

Methodology

We employed phenotypic, molecular docking, and genetic studies to screen for anti-virulence activities among selected promising compounds: Coumarin, Simvastatin, and Ibuprofen.

Results

We found that nearly all detected MRSA and VRSA strains exhibited

SUBMITTER: Bakeer W 

PROVIDER: S-EPMC11381379 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature