Exploring the etiology of dilated cardiomyopathy using Mendelian randomization.

ABSTRACT:

Background

Observational clinical studies suggest an association between dilated cardiomyopathy (DCM) and various factors including titin, cardiac troponin I (CTnI), desmocollin-2, the perinatal period, alcoholism, Behçet's disease, systemic lupus erythematosus, hyperthyroidism and thyrotoxicosis, hypothyroidism, carnitine metabolic disorder, and renal insufficiency. The causal nature of these associations remains uncertain. This study aims to explore these correlations using the Mendelian randomization (MR) approach.

Objective

To investigate the etiology of DCM through Mendelian randomization analysis.

Methods

Data mining was conducted in genome-wide association study databases, focusing on variant target proteins (titin, CTnI, desmocollin-2), the perinatal period, a

SUBMITTER: Xue S 

PROVIDER: S-EPMC11381399 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature