α2,6 sialylation distinguishes a novel active state in CD4⁺ and CD8⁺ cells during acute Toxoplasma gondii infection.

ABSTRACT: Toxoplasmosis is a worldwide parasitosis that is usually asymptomatic; cell-mediated immunity, particularly T cells, is a crucial mediator of the immune response against this parasite. Membrane protein expression has been studied for a long time in T lymphocytes, providing vital information to determine functional checkpoints. However, less is known about the role of post-translational modifications in T cell function. Glycosylation plays essential roles during maturation and function; particularly, sialic acid modulation is determinant for accurate T cell regulation of processes like adhesion, cell-cell communication, and apoptosis induction. Despite its importance, the role of T cell sialylation during infection remains unclear. Herein, we aimed to evaluate whether different membrane sia

SUBMITTER: Sierra-Ulloa D 

PROVIDER: S-EPMC11381403 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature