Heterogeneity in immune cell composition is associated with Mycobacterium tuberculosis replication at the granuloma level.

ABSTRACT: The control of bacterial growth is key to the prevention and treatment of tuberculosis (TB). Granulomas represent independent foci of the host immune response that present heterogeneous capacity for control of bacterial growth. At the whole tissue level, B cells and CD4 or CD8 T cells have an established role in immune protection against TB. Immune cells interact within each granuloma response, but the impact of granuloma immune composition on bacterial replication remains unknown. Here we investigate the associations between immune cell composition, including B cell, CD4, and CD8 T cells, and the state of replicating Mycobacterium tuberculosis (Mtb) within the granuloma. A measure of ribosomal RNA synthesis, the RS ratio®, represents a proxy measure of Mtb replication

SUBMITTER: Cooper SK 

PROVIDER: S-EPMC11381408 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature