Perioperative Serum MicroRNA 371a-3p and 372-3p Levels in Patients with Clinically Localized Testicular Masses.

ABSTRACT:

Background

MicroRNAs (miRNAs) show promise as blood-based tumor markers for germ cell tumors (GCTs), with miRNA-371-3p being the most studied. The marginal benefit of including other candidate miRNAs to aid with the management of testicular GCTs remains unclear.

Objective

To assess the performance of our combined miRNA assay (371a-3p and 372-3p) in patients with clinically localized testicular masses.

Design setting and participants

This was a retrospective review of patients prospectively enrolled in an ongoing protocol collecting serum miR-371a-3p and miR-372-3p levels (together, Memorial Sloan Kettering Cancer Center [MSK] miRNA assay [MMA]) in patients with a suspected or diagnosed testicular GCT.

Outcome measurements and statistical analysis

The coprimary

SUBMITTER: Matulewicz RS 

PROVIDER: S-EPMC11381432 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature