Delta radiomics to track radiation response in lung tumors receiving stereotactic magnetic resonance-guided radiotherapy.

ABSTRACT:

Background and purpose

Lung cancer is a leading cause of cancer-related mortality, and stereotactic body radiotherapy (SBRT) has become a standard treatment for early-stage lung cancer. However, the heterogeneous response to radiation at the tumor level poses challenges. Currently, standardized dosage regimens lack adaptation based on individual patient or tumor characteristics. Thus, we explore the potential of delta radiomics from on-treatment magnetic resonance (MR) imaging to track radiation dose response, inform personalized radiotherapy dosing, and predict outcomes.

Materials and methods

A retrospective study of 47 MR-guided lung SBRT treatments for 39 patients was conducted. Radiomic features were extracted using Pyradiomics, and stability was evaluated temporally and

SUBMITTER: Zha Y 

PROVIDER: S-EPMC11381448 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature