TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma.

ABSTRACT: Immune memory has been expanded to group 2 innate lymphoid cells (ILC2s), but the cellular and molecular bases remain incompletely understood. Based on house dust mite (HDM)-induced mice asthma models and human samples, we applied flow cytometry, parabiosis, in vivo imaging and adoptive transplantation to confirm the persistence, migration and function of CD45⁺lineage^-CD90.2⁺NK1.1^-NKp46^-ST2^-KLRG1⁺IL-17RB⁺ memory-like ILC2s (ml-ILC2s). Regulated by CCR9/CCL25 and S1P signaling, ml-ILC2s reside in the lamina propria of small intestines (siLP) in asthma remission, and subsequently move to airway upon re-encountering antigens or alarmins. Furthermore, ml-ILC2s possess properties of longevity, potential of r

SUBMITTER: Bao K 

PROVIDER: S-EPMC11381517 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature