Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes.

ABSTRACT: In mammalian ovary, the primordial follicle pool serves as the source of developing follicles and fertilizable ova. To maintain the normal length of female reproductive life, the primordial follicles must have adequate number and be kept in a quiescent state before menopause. However, the molecular mechanisms underlying primordial follicle survival are poorly understood. Here, we provide genetic evidence showing that lacking protein phosphatase 4 (PPP4) in oocytes, a member of PP2A-like subfamily, results in infertility in female mice. A large quantity of primordial follicles has been depleted around the primordial follicle pool formation phase and the ovarian reserve is exhausted at about 7 months old. Further investigation demonstrates that depletion of PPP4 causes the abnormal activatio

SUBMITTER: Dong MZ 

PROVIDER: S-EPMC11381532 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature