Plasma proteomic signature of neonates in the context of placental histological chorioamnionitis.

ABSTRACT:

Background

Placental histological chorioamnionitis (HCA) is recognised as a significant risk factor for various adverse neonatal outcomes. This study aims to explore if the inflammatory protein levels in neonates were associated with HCA.

Methods

All women with singleton births from February 2020 to November 2022 were selected and divided into three groups based on maternal placental pathology results: the HCA-stage 1 group (n=24), the HCA-stage 2 group (n=16) and the control group (n=17). Olink Target 96 Inflammation Panel was used to detect the levels of 92 inflammation-related proteins in the plasma of newborns from all three groups within 24 hours after birth. We compared the protein profiles through differential protein expression analysis.

Results

A total of six

SUBMITTER: Liu J 

PROVIDER: S-EPMC11381644 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature