Implementing a pharmacogenomic-driven algorithm to guide antiplatelet therapy among Caribbean Hispanics: a non-randomised clinical trial.

ABSTRACT:

Objectives

To assess whether genotype-guided selection of oral antiplatelet drugs using a clinical decision support (CDS) algorithm reduces the rate of major adverse cardiovascular and cerebrovascular events (MACCEs) among Caribbean Hispanic patients, after 6 months.

Design

An open-label, multicentre, non-randomised clinical trial.

Setting

Eight secondary and tertiary care hospitals (public and private) in Puerto Rico.

Participants

300 Caribbean Hispanic patients on clopidogrel, both genders, underwent percutaneous coronary intervention (PCI) for acute coronary syndromes, stable ischaemic heart disease and documented extracardiac vascular diseases.

Interventions

Patients were separated into standard-of-care (SoC) and genotype-guided (pharmacogenetic (PGx

SUBMITTER: Nunez-Medina HJ 

PROVIDER: S-EPMC11381646 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature