Evaluation of magnetic resonance imaging derived synthetic computed tomography for proton therapy planning in prostate cancer.

ABSTRACT:

Background and purpose

Magnetic resonance imaging (MRI)-only workflow is used in photon radiotherapy (RT) today, but not yet for protons. To bring MRI-only proton RT into clinical use, proton dose calculation on MRI-derived synthetic CT (sCT) must be validated. We evaluated proton dose calculation accuracy of prostate cancer proton plans using a commercially available sCT generator already validated for photon planning.

Materials and methods

The retrospective planning study included 10 prostate cancer patients who underwent MRI and planning CT (pCT) before RT. sCT were generated from the MRI with MRI Planner v2.3, and compared to pCT using structural mean absolute error (MAE). The pCT was used to create one-arc volumetric modulated arc therapy (VMAT) photon plan and two-fiel

SUBMITTER: Fridstrom KML 

PROVIDER: S-EPMC11381754 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature