Sex differences in the roles of nicotine use and puberty on youth C-reactive protein levels: Effects above and beyond adversity.

ABSTRACT: Inflammation likely mediates associations between nicotine use and negative health outcomes. Sex differences have been observed in nicotine use-inflammation links, and physiological processes during puberty might allow for these differences to arise. In this cross-sectional study of 498 youth (ages 8-13, 52% girls, 77% with history of child maltreatment (CM) investigation), sex-differentiated associations between self-reported nicotine use and high-sensitivity C-reactive protein (hs-CRP) were explored. Additionally, self-reported pubertal stage was investigated as a moderator of such nicotine use-hs-CRP links. Hierarchical generalized estimating equation models were adjusted for a wide range of adversity effects: CM investigation history derived from state records, self- and caregiver-repo

SUBMITTER: Pham HT 

PROVIDER: S-EPMC11381809 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature