Domain-knowledge enabled ensemble learning of 5-formylcytosine (f5C) modification sites.

ABSTRACT: 5-formylcytidine (f⁵C) is a unique post-transcriptional RNA modification found in mRNA and tRNA at the wobble site, playing a crucial role in mitochondrial protein synthesis and potentially contributing to the regulation of translation. Recent studies have unveiled that the f⁵C modifications may drive mitochondrial mRNA translation to power cancer metastasis. Accurate identification of f⁵C sites is essential for further unraveling their molecular functions and regulatory mechanisms, but there are currently no computational methods available for predicting their locations. In this study, we introduce an innovative ensemble approach, successfully enabling the computational recognition of Saccharomyces cerevisiae f⁵C. We conducted a comprehen

SUBMITTER: Huang J 

PROVIDER: S-EPMC11381828 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature