Systemic oxidative stress associates with the development of post-COVID-19 syndrome in non-hospitalized individuals.

ABSTRACT:

Background

Post-COVID-19 syndrome (PCS) remains a major health issue worldwide, while its pathophysiology is still poorly understood. Systemic oxidative stress (OS) may be involved in PCS, which is reflected by lower circulating free thiols (R-SH, sulfhydryl groups), as they are receptive to rapid oxidation by reactive species. This study aimed to investigate the longitudinal dynamics of serum R-SH after SARS-CoV-2 infection and its association with the development of PCS in individuals with mild COVID-19.

Methods

Baseline serum R-SH concentrations were measured and compared between 135 non-hospitalized COVID-19 subjects and 82 healthy controls (HC). In COVID-19 subjects, serum R-SH concentrations were longitudinally measured during the acute disease phase (up to 3 weeks) an

SUBMITTER: Vlaming-van Eijk LE 

PROVIDER: S-EPMC11381883 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature