Lung-brain crosstalk: Behavioral disorders and neuroinflammation in septic survivor mice.

ABSTRACT: Although studies have suggested an association between lung infections and increased risk of neuronal disorders (e.g., dementia, cognitive impairment, and depressive and anxious behaviors), its mechanisms remain unclear. Thus, an experimental mice model of pulmonary sepsis was developed to investigate the relationship between lung and brain inflammation. Male Swiss mice were randomly assigned to either pneumosepsis or control groups. Pneumosepsis was induced by intratracheal instillation of Klebsiella pneumoniae, while the control group received a buffer solution. The model's validation included assessing systemic markers, as well as tissue vascular permeability. Depression- and anxiety-like behaviors and cognitive function were assessed for 30 days in sepsis survivor mice, inflamma

SUBMITTER: Bonorino KC 

PROVIDER: S-EPMC11381903 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature