Heat shock transcription factor 1 facilitates liver cancer progression by driving super-enhancer-mediated transcription of MYCN.

ABSTRACT:

Background

Heat shock transcription factors (HSFs) play crucial roles in the development of malignancies. However, the specific roles of HSFs in hepatocellular carcinoma (HCC) have yet to be fully elucidated.

Aims

To explore the involvement of the HSF family, particularly HSF1, in the progression and prognosis of HCC.

Materials & methods

We conducted a thorough analysis of HSF expression and copy number variations across various cancer datasets. Specifically focusing on HSF1, we examined its expression levels and prognostic implications in HCC. In vitro and in vivo experiments were carried out to evaluate the impact of HSF1 on liver cancer cell proliferation. Additionally, we utilized CUT&Tag, H3K27 acetylation enrichment, and RNA sequencing (RNA-seq) to investigate t

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11382014 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature