A high-throughput system for drug screening based on the movement analysis of zebrafish.

ABSTRACT: Zebrafish is a highly advantageous model animal for drug screening and toxicity evaluation thanks to its amenability to optical imaging (i.e., transparency), possession of organ structures similar to humans, and the ease with which disease models can be established. However, current zebrafish drug screening technologies and devices suffer from limitations such as low level of automation and throughput, and low accuracy caused by the heterogeneity among individual zebrafish specimens. To address these issues, we herein develop a high-throughput zebrafish drug screening system. This system is capable of maintaining optimal culturing conditions and simultaneously monitoring and analyzing the movement of 288 zebrafish larvae under various external conditions, such as drug combinations. Moreove

SUBMITTER: Zhao X 

PROVIDER: S-EPMC11382040 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature