IGFBP1 promotes the proliferation and migration of lung adenocarcinoma cells through the PPARα pathway.

ABSTRACT:

Background

The immune status is closely linked to cancer progression, metastasis, and prognosis. Lipid metabolism, crucial for reshaping immune status, plays a key role in regulating the advancement of lung adenocarcinoma (LUAD) and deserves further investigation.

Methods

This study classifies LUAD patients into different immune subtypes based on lipid metabolism-related genes and compares the clinical characteristics among these subtypes. Single-multi COX analysis screens out key genes related to prognosis, and a risk feature and prognostic model are constructed. Cell cloning, scratch, transwell, western blotting and flow cytometry cell cycle analysis to detect the function of key genes. A subcutaneous tumor animal model is used to investigate the in vivo function and molec

SUBMITTER: Li Y 

PROVIDER: S-EPMC11382126 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature