Data-Driven Insights into the Transition-Metal-Catalyzed Asymmetric Hydrogenation of Olefins.

ABSTRACT: The transition-metal-catalyzed asymmetric hydrogenation of olefins is one of the key transformations with great utility in various industrial applications. The field has been dominated by the use of noble metal catalysts, such as iridium and rhodium. The reactions with the earth-abundant cobalt metal have increased only in recent years. In this work, we analyze the large amount of literature data available on iridium- and rhodium-catalyzed asymmetric hydrogenation. The limited data on reactions using Co catalysts are then examined in the context of Ir and Rh to obtain a better understanding of the reactivity pattern. A detailed data-driven study of the types of olefins, ligands, and reaction conditions such as solvent, temperature, and pressure is carried out. Our analysis provides an unde

SUBMITTER: Singh S 

PROVIDER: S-EPMC11382158 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature