Prognostic significance of serum secreted frizzled-related protein 5 in patients with acute aortic dissection.

ABSTRACT:

Background

Secreted frizzled-related protein 5 (SFRP5) is a novel adipokine that has been found to be closely associated with metabolic and cardiovascular diseases. We investigated serum SFRP5 levels during the acute phase and their predictive value for the prognosis of acute aortic dissection (AAD).

Methods

In total, 152 AAD patients and 164 controls were enrolled in this study. Serum SFRP5 levels were measured using an enzyme-linked immunosorbent assay (ELISA). AAD patients were divided into high-SFRP5 and low-SFRP5 groups based on the optimal cutoff value and followed up for prognosis. The primary endpoint was all-cause mortality, and the secondary endpoint focused on AAD-related events (including AAD-related mortality and unplanned reoperations).

Results

Serum SFR

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11382199 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature