Causal associations between COVID-19 and erectile dysfunction: a Mendelian randomization study.

ABSTRACT:

Objective

In this study, we aimed to explore the potential association between COVID-19 infection, hospitalization, severe COVID-19, and erection dysfunction (ED) using the two-sample Mendelian randomization (MR) method.

Methods

Data pertaining to COVID-19 were extracted from the latest version of the COVID-19 Host Genetics Initiative genome-wide association study (GWAS) meta-analyses (Round 7, April 2022), and outcome data were obtained from the Open GWAS database. We applied various MR analysis methods, including the inverse variance weighted method, weighted median method, and MR-Egger regression.

Results

Our investigation revealed a negative causal association between COVID-19 hospitalization and ED (total testosterone levels: beta = -0.026; 95% confidence interva

SUBMITTER: Ma C 

PROVIDER: S-EPMC11382218 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature