Influence of Selective Deoxyfluorination on the Molecular Structure of Type-2 N-Acetyllactosamine.

ABSTRACT: N-Acetyllactosamine is a common saccharide motif found in various biologically active glycans. This motif usually works as a backbone for additional modifications and thus significantly influences glycan conformational behavior and biological activity. In this work, we have investigated the type-2 N-acetyllactosamine scaffold using the complete series of its monodeoxyfluorinated analogs. These glycomimetics have been studied by molecular mechanics, quantum mechanics, X-ray crystallography, and various NMR techniques, which have provided a comprehensive and complete insight into the role of individual hydroxyl groups in the conformational behavior and lipophilicity of N-acetyllactosamine.

SUBMITTER: Kurfirt M 

PROVIDER: S-EPMC11382267 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature