Acquired platelet defects are responsible for nonsurgical bleeding in left ventricular assist device recipients.

ABSTRACT:

Background

Left ventricular assist devices (LVADs) have been used as a standard treatment option for patients with advanced heart failure. However, these devices are prone to adverse events. Nonsurgical bleeding (NSB) is the most common complication in patients with continuous flow (CF) LVADs. The development of acquired von Willebrand syndrome (AVWS) in CF-LVAD recipients is thought to be a key factor. However, AVWS is seen across a majority of LVAD patients, not just those with NSB. The purpose of this study was to examine the link between acquired platelet defects and NSB in CF-LVAD patients.

Methods

Blood samples were collected from 62 CF-LVAD patients at pre- and 4 post-implantation timepoints. Reduced adhesion receptor expression (GPIbα and GPVI) and activation of plat

SUBMITTER: Arias K 

PROVIDER: S-EPMC11382350 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature