Fabrication of 3D Biomimetic Smooth Muscle Using Magnetic Induction and Bioprinting for Tissue Regeneration.

ABSTRACT: Smooth muscles play a vital role in peristalsis, tissue constriction, and relaxation but lack adequate self-repair capability for addressing extensive muscle defects. Engineering scaffolds have been broadly proposed to repair the muscle tissue. However, efforts to date have shown that those engineered scaffolds focus on cell alignment in 2-dimension (2D) and fail to direct muscle cells to align in 3D area, which is irresolvable to remodel the muscle architecture and restore the muscle functions like contraction and relaxation. Herein, we introduced an iron oxide (Fe₃O₄) filament-embedded gelatin (Gel)-silk fibroin composite hydrogel in which the oriented Fe₃O₄ self-assembled and functioned as micro/nanoscale geometric cues to induce cell alignmen

SUBMITTER: Luo Y 

PROVIDER: S-EPMC11382380 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature