Association of free fatty acid in first trimester with the risk of gestational diabetes mellitus: a nested case-control study.

ABSTRACT:

Background

Accumulating evidence shows that free fatty acids (FFA) are associated with gestational diabetes mellitus (GDM). However, most of the studies focus on a few specific types of FFA, such as α-linolenic acid (C18:3n3) and Arachidonic acid (C20:4n6) or a total level of FFA.

Objective

This study aimed to test the association between a variety of FFAs during the first trimester and the risk of GDM.

Methods

The participants came from the Zhoushan Pregnant Women Cohort (ZWPC). A 1:2 nested case-control study was conducted: fifty mothers with GDM were matched with 100 mothers without GDM by age, pre-pregnancy body mass index (BMI), month of oral glucose tolerance test (OGTT) and parity. Thirty-seven FFAs (including 17 saturated fatty acids (SFA), 8 monounsaturated f

SUBMITTER: Pu L 

PROVIDER: S-EPMC11382404 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature