Hypoxia-induced BAP1 enhances erastin-induced ferroptosis in nasopharyngeal carcinoma by stabilizing H2A.

ABSTRACT:

Background

Hypoxia plays an important role in the chemotherapy resistance of nasopharyngeal carcinoma (NPC). Ferroptosis is a newly discovered form of programmed cell death and ferroptosis inducers showed promising therapeutic effects in some cancers. However, the sensibility of NPC cells to ferroptosis under the hypoxic microenvironment is still unclear, and this study was designed to clarify it.

Methods

NPC cells, treated with erastin, were placed in a normoxia or hypoxic environment (5% CO₂, 94% N₂ and 1% O₂) at 37℃for 24 h. After exposed to hypoxia, ferroptosis-associated phenotypes were detected by CCK8, MDA, GSH, lipid ROS and Fe. The gene expression profiles of head and neck squamous cell carcinoma (HNSCC) tissues were downloaded from

SUBMITTER: Cai W 

PROVIDER: S-EPMC11382407 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature