Stem cell-derived extracellular vesicles in premature ovarian failure: an up-to-date meta-analysis of animal studies.

ABSTRACT:

Background

There has been a significant surge in animal studies of stem cell-derived extracellular vesicles (EVs) therapy for the treatment of premature ovarian failure (POF) but its efficacy remains unknown and a comprehensive and up-to-date meta-analysis is lacking. Before clinical translation, it is crucial to thoroughly understand the overall impact of stem cell-derived EVs on POF.

Methods

PubMed, EMBASE, Cochrane Library, Web of Science were searched up to February 18, 2024. The risk of bias was evaluated according to Cochrane Handbook criteria, while quality of evidence was assessed using the SYRCLE system. The PRISMA guidance was followed. Trial sequential analysis was conducted to assess outcomes, and sensitivity analysis and publication bias analysis were performed

SUBMITTER: Luo Y 

PROVIDER: S-EPMC11382489 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature