Transmission-blocking activities of artesunate, chloroquine, and methylene blue on <i>Plasmodium vivax</i> gametocytes.

ABSTRACT: Plasmodium vivax is now the main cause of malaria outside Africa. The gametocytocidal effects of antimalarial drugs are important to reduce malaria transmissibility, particularly in low-transmission settings, but they are not well characterized for P. vivax. The transmission-blocking effects of chloroquine, artesunate, and methylene blue on P. vivax gametocytes were assessed. Blood specimens were collected from patients presenting with vivax malaria, incubated with or without the tested drugs, and then fed to mosquitos from a laboratory-adapted colony of Anopheles dirus (a major malaria vector in Southeast Asia). The effects on oocyst and sporozoite development were analyzed under a multi-level Bayesian model accounting for assay variability and the heterogeneit

SUBMITTER: Chaumeau V 

PROVIDER: S-EPMC11382624 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature