An unusual Toll/MyD88-mediated Drosophila host defence against Talaromyces marneffei.

ABSTRACT: Talaromycosis, caused by Talaromyces marneffei (T. marneffei, formerly known as Penicillium marneffei), is an opportunistic invasive mycosis endemic in tropical and subtropical areas of Asia with high mortality rate. Despite various infection models established to study the immunological interaction between T. marneffei and the host, the pathogenicity of this fungus is not yet fully understood. So far, Drosophila melanogaster, a well-established genetic model organism to study innate immunity, has not been used in related research on T. marneffei. In this study, we provide the initial characterization of a systemic infection model of T. marneffei in the D. melanogaster host. Survival curves and fungal loads were tested as well as Toll

SUBMITTER: Wang X 

PROVIDER: S-EPMC11382710 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature