Causal Association Between Atopic Dermatitis and Keratoconus: A Mendelian Randomization Study.

ABSTRACT:

Purpose

Although many studies have indicated that atopic dermatitis (AD) could contribute to the risk of keratoconus (KC), the causality between AD and KC remains controversial. This study aimed to explore the potential causal associations between AD and KC.

Methods

Instrumental variables for both exposures and outcomes were obtained from large-scale genome-wide association study summary statistics from previous meta-analyses. Mendelian randomization (MR) was applied to infer causal associations between AD and KC. Our main analyses were conducted by inverse-variance weighted (IVW) method multiplicative random effect model, complemented with additional five models and sensitivity analyses. Reverse MR analysis was applied to determine the direction of the causal association be

SUBMITTER: Chang Y 

PROVIDER: S-EPMC11382964 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature