StrIDR: a database of intrinsically disordered regions of proteins with experimentally resolved structures.

ABSTRACT:

Motivation

Intrinsically disordered regions (IDRs) of proteins exist as an ensemble of conformations, and not as a single structure. Existing databases contain extensive, experimentally derived annotations of intrinsic disorder for millions of proteins at the sequence level. However, only a tiny fraction of these IDRs are associated with an experimentally determined protein structure. Moreover, even if a structure exists, parts of the disordered regions may still be unresolved.

Results

Here we organize Structures of Intrinsically Disordered Regions (StrIDR), a database of IDRs confirmed via experimental or homology-based evidence, resolved in experimentally determined structures. The database can provide useful insights into the dynamics, f

SUBMITTER: Majila K 

PROVIDER: S-EPMC11382991 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature