Aryl Hydrocarbon Receptor Activation Drives 2-Methoxy Estradiol Secretion in Human Trophoblast Stem Cell Development.

ABSTRACT:

Study question

How does activation of AHR signaling affect human trophoblast cell development and differentiation?

Summary answer

AHR activation leads to altered gene expression but does not hinder the ability of trophoblast cells to remain in a stem cell state or differentiate into essential cell types, such as extravillous trophoblast cells (EVT) or syncytiotrophoblast (ST). It also promotes the production of 2 methoxy estradiol (2ME), a compound that could influence placental development.

What is known already

The placenta serves both as a nutrient delivery system and a protective barrier against environmental toxins. AHR signaling is known to mediate cellular responses to environmental pollutants, potentially affecting trophoblast cell functions, but the specific

SUBMITTER: Shukla V 

PROVIDER: S-EPMC11383004 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature