Three types of actomyosin rings within a common cytoplasm exhibit distinct modes of contractility.

ABSTRACT: Actomyosin rings are specializations of the non-muscle actomyosin cytoskeleton that drive cell shape changes during division, wound healing, and other events. Contractile rings throughout phylogeny and in a range of cellular contexts are built from conserved components including non-muscle myosin II, actin filaments, and crosslinking proteins. To explore whether diverse actomyosin rings generate contractile force and close via a common mechanism, we studied three instances of ring closure within the continuous cytoplasm of the C. elegans syncytial oogenic germline: mitotic cytokinesis of germline stem cells, apoptosis of meiotic compartments, and cellularization of oocytes. The three ring types exhibited distinct closure kinetics and component protein abundance dyanmics. We formulat

SUBMITTER: Linehan JB 

PROVIDER: S-EPMC11383051 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature