Behavioral timescale synaptic plasticity in the hippocampus creates non-spatial representations during learning and is modulated by entorhinal inputs.

ABSTRACT: Behavioral timescale synaptic plasticity (BTSP) is a form of synaptic potentiation where a single plateau potential in hippocampal neurons forms a place field during spatial learning. We asked whether BTSP can also form non-spatial responses in the hippocampus and what roles the medial and lateral entorhinal cortex (MEC and LEC) play in driving non-spatial BTSP. Two-photon calcium imaging of dorsal CA1 neurons while mice performed an odor-cued working memory task revealed plateau-like events which formed stable odor-specific responses. These BTSP-like events were much more frequent during the first day of task learning, suggesting that BTSP may be important for early learning. Strong single-neuron stimulation through holographic optogenetics induced plateau-like events and subsequent odor-

SUBMITTER: Dorian CC 

PROVIDER: S-EPMC11383060 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature